A new type of ‘Mini Brain’ Developed : Research is going on continuously for the purpose of solving the complex system of the brain. According to the news report published in Dainik Jagran newspaper, in this sequence, British researchers have developed such a new ‘Mini Brain’, which can lead to fatal and incurable neurological disorders like Paralysis and Dementia. ) and it will be easier to find ways to prevent these diseases and find cures. Although this is not the first time that scientists have developed mini brains from cells from people suffering from neurodegenerative diseases, they have been able to grow in a relatively short time compared to all efforts so far. Success has been achieved. In this sense, this is the first time that scientists from the University of Cambridge have developed this small organ-like model (organoids) brain, which will last for about a year.
The common motor neuron disease amyotrophic lateral sclerosis often overlaps with frontotemporal dementia (ALS/FTD). This disease usually occurs after the age of 40-45 years. In this, the muscles become weak and there is a change in memory, behavior and personality.
Models built for 240 days
The findings of this research, published in the Nature Neuroscience Journal, states that the team created these models from stem cells for 240 days, in which the common genetic mutation in ALS / FTD ) happened. This was not possible in earlier research. Not only this, in an unpublished research it has been told to develop it for 340 days.
cause of disease
András Lakatos, from the Department of Clinical Neurosciences, University of Cambridge, explains that neurodegenerative disorders are very complex and they affect many types of cells, in which over time, The disease progresses due to the reactions of the cells.
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Dr Lakatos further explains that to understand these complications, we need models that last longer and replicate the cellular structure of the human brain so that the changes occurring in them are understood deeply. can go Our model will give this opportunity.
What’s special about the new model
Dr. Lakatos says that with this model we will not only be able to understand what happens before the symptoms of the disease appear, as well as see what kind of changes occur in the cells over time. Organoids usually Cells grow in a ball-like form, but this research team has grown organoids containing patients’ cells in slice culture in the laboratory.
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This technique ensures that most of the model cells get the nutrition they need to survive. Because of this, the team also got to see early changes in the cells of the organoids.
This is how muscle movement is affected
With this, cellular stress, damage to DNA and the mechanism of expression of DNA in proteins can also be tested. These changes also affect nerve cells and other cells in the brain, called astroglia, which are involved in muscle movement and mental capacity.
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help develop treatment
Organoids developed from this new research will not only know about the disease, but it can also be used in the screening of potential drugs. Based on this, the way for developing new medicines can also be paved. The research team has shown that a drug called GSK 2606414 has been effective in relieving the cellular problems common in ALS/FTD. This may lead to the discovery of new ways of treatment by inhibiting processes such as accumulation of toxic proteins, cellular stress and loss of nerve cells.
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